Part 1 of Volume 4 of Series e A: Cardiovascular Diseases and Translational Medicine, provides a foundation for understanding a rapidly developing, growing scientific endeavor that is transcending laboratory testing of hypotheses and providing guidance for:
Target genomes and multiple nucleotide sequences involved in coding or regulation that could have an impact on complex diseases, not necessarily genetic in nature.
Targeting signaling pathways that have been shown to be maladaptive, activated, or suppressed in many common and complex diseases, or in their progression.
Enable a reduction in failure due to toxicities in the later stages of clinical drug trials as a result of this science-based understanding.
Allow a reduction in complications derived from the improvement of mechanical devices that have already impacted the practice of interventional procedures in cardiology, cardiac surgery and radiology, as well as improve laboratory diagnoses at the molecular level.
Enable the discovery of new drugs in the continuing emergence of drug resistance.
Allow the construction of critical pathways and better guidelines for patient management based on population outcome data, which will critically depend on computational methods and large databases.
What has been presented can be seen essentially in the following table:
MT Summary Table - Part 1
MT Summary Table - Part 1
There are some developments that deserve further development:
1. The importance of mitochondrial function in the state of activity of mitochondria in cellular work (combustion) is understood and function alterations are identified in muscle diseases, cardiac contraction, nerve conduction, ion transport , the water balance and the cytoskeleton. beyond messy metabolism in cancer. A more detailed explanation of the energy that was elucidated based on the electron transport chain might also be in order.
2. The processes that allow a more complete application of technology to a series of problems in the environment in which we live and in the modification of diseases are growing rapidly and will change the face of medicine and its related health sciences.
Electron transport and bioenergetics
Deferred by topic of metabolomics
Introduction to synthetic biology and metabolic engineering
http://www.ibiology.org Speakers generously donate their time to prepare for these lectures. The project is funded by NSF and NIGMS, and is supported by ASCB and HHMI.
Dr. Prather explains that synthetic biology involves applying engineering principles to biological systems to build "biological machines."
Dr. Prather has received numerous awards for both her innovative research and her excellence in teaching. Learn more about how Kris became a scientist at
Prather 1: Synthetic Biology and Metabolic Engineering 2/6/14 Introduction Lecture Overview In the first part of her lecture, Dr. Prather explains that synthetic biology involves applying engineering principles to biological systems to build “biological machines. ”. The key material in the construction of these machines is synthetic DNA. Synthetic DNA can be added in different combinations to biological hosts, such as bacteria, turning them into chemical factories that can produce small molecules of choice. In Part 2, Prather describes how her lab used design principles to engineer E. coli that makes glucaric acid from glucose. Glucaric acid does not occur naturally in bacteria, so Prather and her colleagues "bioprospect" enzymes from other organisms and expressed them in E. coli to build the necessary enzymatic pathway. Prather guides us through the many steps to optimize the timing, localization, and expression levels of enzymes to produce the highest yield. Speaker Bio: Kristala Jones Prather received her S.B. She graduated from the Massachusetts Institute of Technology and her Ph.D. from the University of California, Berkeley, both in chemical engineering. After graduating, Prather joined Merck Research Labs for 4 years before returning to academia. Prather is now an associate professor of chemical engineering at MIT and a researcher at Cen