panel app Archives - Gen9 Genetics

We are pleased to announce the launch of the NHS Genomic Medicine Service (GMS) panel resource, which provides a view of the 173 signed panels that relate to genomic tests listed in the NHS National Genomic Test Directory. This platform contains only "green" (level of diagnostic evidence) genes, STRs and (CNV) regions that have been approved for diagnostic testing on the NHS England and is intended for NHS users and clinicians.

The main Genomics England PanelApp knowledge base here will be dedicated for use by the wider scientific community for visualization and review of genes / genomic entities in virtual gene panels and will continue to be updated by Genomics England curators.

For more information on the content evaluation and approval process for GMS-approved panels, please see the NHS National Directory of Genomic Testing website update.

Click here to go to the NHS GMS panels resource

What is PanelApp?
Genomics England PanelApp is a publicly available knowledge base for creating, storing and querying virtual gene panels related to human disorders. It includes a crowdsourcing tool that allows experts from the global scientific community to add or review genes and genomic entities (short tandem repeats / STR and copy number / CNV variants), providing an opportunity for standardization of panels of genes and a consensus. which genes have sufficient evidence for disease association.

Diagnostic grade "green" genes / genomic entities and their modes of inheritance are used in genome interpretation. Originally developed to aid the interpretation of the genomes participating in the 100,000 Genomes Project, PanelApp is now also used as a platform to achieve consensus on gene panels in the NHS Genomic Medicine Service (GMS). Because PanelApp dashboards are publicly available, they can also be used by other groups and projects.