Shank3 Antibody | 355-25486

Product Name:

SHANK3 Antibody

Host Species:

Rabbit

Clonality:

Polyclonal

Purification:

Affinity chromatography purified via peptide column

Applications:

ELISA WB

Species Reactivity:

Hu Ms

Specificity:

At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.

Immunogen Type:

Peptide

Immunogen Description:

19 amino acid peptide near the center of human SHANK3.

Target Name:

SHANK3

Accession No.:

 Swiss-Prot:Q9BYB0

Concentration: 

1mg/ml

Formulation: 

PBS containing 0.02% sodium azide.

Storage: 

Store at 4˚C for three months and -20˚C, stable for up to one year.

Molecular Weight:

190 kDa

Antigen:

Synthetic peptide amino acids 840-857 (PEKLPGSLRKGIPRTKSV) of rat Shank3 (also known as SH3 and multiple ankyrin repeat domains protein 3, prolinerich synapse-associated protein 2, ProSAP2 and SPANK-2, accession number Q9JLU4); Human: 100% identity (18/18 amino acids identical); Mouse: 100% identity (18/18 amino acids identical)

Synonyms:

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)

Target Description:

SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density.

Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.