Description

Rabbit Anti-TYROSINE HYDROXYLASE | 239-P40101-150

Antibodies that detect Tyrosine Hydroxylase can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunohistochemistry. These antibodies target Tyrosine Hydroxylase in Human, Rat, Mouse, Many and Zebrafish samples.

Our Tyrosine Hydroxylase monoclonal, polyclonal, recombinant monoclonal and recombinant polyclonal antibodies are developed in Rabbit, Mouse, Goat and Sheep. These antibodies have been verified by Cell treatment, Relative expression and Knockdown to confirm specificity to Tyrosine Hydroxylase. Find the Tyrosine Hydroxylase antibody that fits your needs. Choose from 1 of 56 Tyrosine Hydroxylase antibodies, which have been validated in experiments with 72 publications and 260 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains.

TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Synonyms

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase

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