Description

Complement C5 beta chain Antibody (FITC) | 13-ORB187181

Mouse monoclonal [aE11] to C5b-9 + C5b-8
Suitable for: ELISA, ICC/IF, Flow Cyt, IHC-Fr
Reacts with: Horse, Human, Pig, Monkey, Baboon
Isotype: IgG2a

Antibodies that detect Complement C5 can be used in several scientific applications, including ELISA, Western Blot, Immunocytochemistry, Immunohistochemistry (Frozen) and Immunohistochemistry (Paraffin). These antibodies target Complement C5 in Human, Mouse and Rat samples. Our Complement C5 polyclonal, monoclonal and recombinant monoclonal antibodies are developed in Rabbit, Mouse, Goat and Sheep.

Find the Complement C5 antibody that fits your needs. Choose from 1 of 12 Complement C5 antibodies, which have been validated in experiments with 8 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

SRC is a non-receptor kinase involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20.

Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.

Synonyms

anaphylatoxin; anaphylatoxin C5; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5; C5a; C5a anaphylatoxin; C5b; C5D; Complement C5; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain; complement component 5; CPAMD4; ECLZB; Hc; He; hemolytic complement; prepro-C5; RGD1561905

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